uppS [2019-07-02 08:02:19]

undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis

Locus: BSU16530

Isoelectric point: 5.41

Molecular weight: 29.63 kDa

Protein length: 260 aa

Gene length: 783 bp

Function: cell wall biosynthesis

Product: undecaprenyl pyrophosphate synthetase

Essential: yes

E.C.: 2.5.1.31

Synonyms: yluA

Genomic Context

Loading

Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of the carrier lipid undecaprenylphosphate
• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of isoprenoids
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of the carrier lipid undecaprenylphosphate
• Groups of genes → Essential genes

Gene

Coordinates: 1,721,214 1,721,996

Phenotypes of a mutant

• essential PubMed
• uppS is dispensable in wall-less L-forms PubMed
• the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed

The protein

Catalyzed reaction/ biological activity

• catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate

Protein family

• UPP synthetase family (according to Swiss-Prot)

Structure

• 1X09 (the protein from E. coli, 49% identity, 77% similarity) PubMed

Expression and Regulation

Operons

• Genes: uppS-cdsA-ispC-rasP-proS-polC
  Description: PubMed

Biological materials

Mutant

• MGNA-B080 (yluA::erm), available at the NBRP B. subtilis, Japan

References

Loading